Receptor-type protein tyrosine phosphatases in cancer.
Identifieur interne : 000344 ( Main/Exploration ); précédent : 000343; suivant : 000345Receptor-type protein tyrosine phosphatases in cancer.
Auteurs : Yu Du [États-Unis] ; Jennifer R. GrandisSource :
- Chinese journal of cancer [ 1000-467X ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- enzymologie : Tumeurs.
- génétique : Receptor-Like Protein Tyrosine Phosphatases.
- physiologie : Receptor-Like Protein Tyrosine Phosphatases.
- Apoptose, Humains, Invasion tumorale, Prolifération cellulaire, Survie cellulaire.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : Receptor-Like Protein Tyrosine Phosphatases.
- enzymology : Neoplasms.
- chemical , physiology : Receptor-Like Protein Tyrosine Phosphatases.
- Apoptosis, Cell Proliferation, Cell Survival, Humans, Neoplasm Invasiveness.
Abstract
Protein tyrosine phosphatases (PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Receptor-type protein tyrosine phosphatases (PTPRs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPRs in cancer and consider the consequences of PTPR alterations in different types of cancers. We also summarize recent developments using PTPRs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPRs in cancer may provide opportunities to improve therapeutic approaches.
DOI: 10.5732/cjc.014.10146
PubMed: 25322863
Affiliations:
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Le document en format XML
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Grandis</name></author></analytic><series><title level="j">Chinese journal of cancer</title><idno type="ISSN">1000-467X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Apoptosis</term><term>Cell Proliferation</term><term>Cell Survival</term><term>Humans</term><term>Neoplasm Invasiveness</term><term>Neoplasms (enzymology)</term><term>Receptor-Like Protein Tyrosine Phosphatases (genetics)</term><term>Receptor-Like Protein Tyrosine Phosphatases (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Apoptose</term><term>Humains</term><term>Invasion tumorale</term><term>Prolifération cellulaire</term><term>Receptor-Like Protein Tyrosine Phosphatases (génétique)</term><term>Receptor-Like Protein Tyrosine Phosphatases (physiologie)</term><term>Survie cellulaire</term><term>Tumeurs (enzymologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptor-Like Protein Tyrosine Phosphatases</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Tumeurs</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Neoplasms</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Receptor-Like Protein Tyrosine Phosphatases</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Receptor-Like Protein Tyrosine Phosphatases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Receptor-Like Protein Tyrosine Phosphatases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Apoptosis</term><term>Cell Proliferation</term><term>Cell Survival</term><term>Humans</term><term>Neoplasm Invasiveness</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Apoptose</term><term>Humains</term><term>Invasion tumorale</term><term>Prolifération cellulaire</term><term>Survie cellulaire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Protein tyrosine phosphatases (PTPs) play an important role in regulating cell signaling events in coordination with tyrosine kinases to control cell proliferation, apoptosis, survival, migration, and invasion. Receptor-type protein tyrosine phosphatases (PTPRs) are a subgroup of PTPs that share a transmembrane domain with resulting similarities in function and target specificity. In this review, we summarize genetic and epigenetic alterations including mutation, deletion, amplification, and promoter methylation of PTPRs in cancer and consider the consequences of PTPR alterations in different types of cancers. We also summarize recent developments using PTPRs as prognostic or predictive biomarkers and/or direct targets. Increased understanding of the role of PTPRs in cancer may provide opportunities to improve therapeutic approaches.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><noCountry><name sortKey="Grandis, Jennifer R" sort="Grandis, Jennifer R" uniqKey="Grandis J" first="Jennifer R" last="Grandis">Jennifer R. Grandis</name></noCountry><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Du, Yu" sort="Du, Yu" uniqKey="Du Y" first="Yu" last="Du">Yu Du</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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